Genetic factors affecting intraoperative 5-aminolevulinic acid-induced fluorescence of diffuse gliomas
نویسندگان
چکیده
منابع مشابه
Genetic Factors Affecting Intraoperative 5-aminolevulinic Acid-induced Fluorescence of Diffuse Gliomas
BACKGROUND In patients operated for malignant glioma, 5-aminolevulinic acid (5-ALA)-induced fluorescence guidance is useful. However, we occasionally experience instances of non-visible fluorescence despite a histopathological diagnosis of high-grade glioma. We sought to identify factors that influence the intraoperative visualization of gliomas by their 5-ALA-induced fluorescence. PATIENTS A...
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BACKGROUND AND OBJECTIVE The clinical usefulness of 5-ALA guided detection of tumor tissue has been demonstrated for a number of malignancies. However, current techniques of intraoperative detection of protoporphyrin IX fluorescence in situ do not offer subcellular resolution. Therefore, discrimination of non-specific 5-ALA induced fluorescence remains difficult. MATERIALS AND METHODS In this...
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OBJECT Bone invasion is a major concern in meningioma surgery, since it is predictive of the recurrence of cranial involvement, morbidity, and mortality. Bone invasion has been reported in 20%-68% of studies with histopathologically confirmed data. Unfortunately, radical resection of bone invasion remains challenging. The aim of this study was to assess the role of 5-aminolevulinic acid (5-ALA)...
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BACKGROUND 5-Aminolevulinic acid (5-ALA) fluorescence is a validated technique for resection of high grade gliomas (HGG); the aim of this study was to evaluate the surgical outcome and the intraoperative findings in a consecutive series of patients. METHODS Clinical and surgical data from patients affected by HGG who underwent surgery guided by 5-ALA fluorescence at our Department between Jun...
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The need for novel, effective, and safe treatments for malignant glioma is obvious. Despite surgery, radiotherapy, and chemotherapy, the median survival time of patients with glioblastoma multiforme (World Health Organization Grade IV) still does not exceed 15 months. Patients with anaplastic astrocytoma (World Health Organization Grade III) have a slightly better prognosis. As a result of the ...
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ژورنال
عنوان ژورنال: Radiology and Oncology
سال: 2017
ISSN: 1581-3207
DOI: 10.1515/raon-2017-0019